Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950188 | 0.77 | TRPV4 (0.38) | ALDH1A1KDM4ETSHRF2PRSS1 | |
| SCHEMBL29818677 | 0.72 | ERN1 (0.64) | ERN1ALDH1A1TDP1TSHRLMNA | |
| SCHEMBL28293621 | 0.71 | ERN1 (0.68) | ERN1PRKDCALDH1A1TDP1KDM4E | |
| SCHEMBL9950008 | 0.68 | CASR (0.36) | ALDH1A1KDM4EF2PRSS1PRSS2 | |
| SCHEMBL9950001 | 0.68 | F2 (0.36) | ALDH1A1KDM4EF2PRSS1PRSS2 | |
| SCHEMBL6192767 | 0.68 | HSD17B10 (0.39) | ALDH1A1KDM4EF2PRSS1PRSS2 | |
| SCHEMBL28275299 | 0.67 | ERN1 (0.64) | ERN1PRKDCALDH1A1TDP1TSHR | |
| SCHEMBL5318058 | 0.67 | ALDH1A1 (0.49) | ALDH1A1KDM4ETSHRTRPV4HPGD | |
| SCHEMBL15352925 | 0.67 | TRPV4 (0.46) | ALDH1A1KDM4ETSHRTRPV4LMNA | |
| SCHEMBL811473 | 0.67 | TRPV4 (0.46) | ALDH1A1KDM4ETSHRTRPV4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041980-B1 | ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6011059-A | PREVENTING OR TREATING ANGINA PECTORIS, CARDIAC DYSFUNCTION, MYOCARDIAL NECROSIS, AND ARRHYTHMIA EMPLOYING THE ABOVE ACYL GUANIDINES. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |