Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223292 | 0.83 | KDM4E (0.39) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13326134 | 0.75 | HPGD (0.47) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29159753 | 0.72 | POLB (0.43) | KDM4EALDH1A1MAPTCREBBPMKNK1 | |
| SCHEMBL5220170 | 0.72 | ALDH1A1 (0.44) | KDM4EHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL1479464 | 0.71 | ALDH1A1 (0.48) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5217332 | 0.71 | KDM4E (0.38) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5217321 | 0.71 | KDM4E (0.38) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5218309 | 0.71 | VCAM1 (0.42) | KDM4EHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL5218597 | 0.71 | HPGD (0.36) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL13229561 | 0.71 | HPGD (0.48) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |