Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190741 | 0.94 | ACP3 (0.33) | MMP2MMP9MMP8MMP13ELANE | |
| SCHEMBL6192554 | 0.90 | MMP2 (0.36) | MMP2MMP9MMP8MMP13CYP2C9 | |
| SCHEMBL6191220 | 0.88 | KDM4A (0.33) | CYP1A2CYP2C9CYP2C19HTR2AACP3 | |
| SCHEMBL6191349 | 0.84 | ACP3 (0.38) | CYP2C19ACP3MEN1KMT2ACYP3A4 | |
| SCHEMBL6186075 | 0.82 | MMP2 (0.33) | MMP2MMP9MMP8MMP13CYP1A2 | |
| SCHEMBL6192154 | 0.80 | CYP1A2 (0.34) | MMP2MMP9MMP8MMP13CYP1A2 | |
| SCHEMBL6173668 | 0.78 | OPRD1 (0.41) | MMP2MMP9MMP8MMP13CYP1A2 | |
| SCHEMBL6188226 | 0.78 | HTR2A (0.38) | CYP2C9HTR2A | |
| SCHEMBL6191058 | 0.77 | KDM4A (0.34) | HTR2A | |
| SCHEMBL6189771 | 0.74 | MLNR (0.34) | CYP2C9ELANEHTR2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |