Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1058430 | 0.84 | HDAC1 (0.62) | KDM4ELMNAUSP2HDAC1 | |
| SCHEMBL13713693 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1PKMKDM4E | |
| SCHEMBL1065171 | 0.76 | KMT2A (0.52) | ALDH1A1KMT2AMEN1PKMKDM4E | |
| SCHEMBL3557879 | 0.74 | HDAC1 (0.53) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL10579147 | 0.65 | FAAH (0.67) | NR1H4ALDH1A1KMT2AMEN1PKM | |
| SCHEMBL211529 | 0.65 | HDAC1 (0.58) | ALDH1A1KMT2APKMKDM4EHTT | |
| SCHEMBL8346243 | 0.62 | HDAC1 (0.54) | HDAC1 | |
| SCHEMBL14503122 | 0.62 | GALR2 (0.66) | ALDH1A1KMT2AMEN1KDM4EHTT | |
| SCHEMBL3142795 | 0.61 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1KDM4EHTT | |
| SCHEMBL7933991 | 0.61 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590340-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |