Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | APAF1 | O14727 | 2/20 | 0.47 |
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809304 | 0.81 | HSP90AA1 (0.76) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL7955080 | 0.80 | HSP90AA1 (0.61) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6188701 | 0.78 | MAPT (0.83) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL10909532 | 0.75 | HSP90AA1 (0.58) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8092987 | 0.74 | HSP90AA1 (0.61) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6192695 | 0.74 | MAPT (0.50) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL12653440 | 0.73 | MAPK1 (0.49) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6192726 | 0.73 | MALT1 (0.49) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL20046948 | 0.72 | HSP90AA1 (0.46) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL11218447 | 0.72 | HSP90AA1 (0.63) | MAPTMAPK1ALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100436425-C | Fused imidazolium derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 2008-11-26 | — | — | CN | disclosed |
| EP-1256576-B1 | FUSED IMIDAZOLIUM DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-6734203-B2 | ANTI-CANCERS AND ANTITUMOR AGENTS | ASTELLAS PHARMA INC. (JP) | 2004-05-11 | — | — | US | disclosed |
| US-20030114508-A1 | Fused imidazolium derivatives | ASTELLAS PHARMA INC. (JP) | 2003-06-19 | — | — | US | disclosed |
| CN-1400969-A | Fused imidazolium derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 2003-03-05 | — | — | CN | disclosed |
| EP-1256576-A1 | FUSED IMIDAZOLIUM DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114508-A1 | Fused imidazolium derivatives | TP53, HRAS, BCOR | MAPT 4795/4885MAPK1 4540/4885ALDH1A1 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.