Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809304 | 0.88 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL17594608 | 0.81 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL8102106 | 0.81 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL6190075 | 0.80 | MAPT (0.54) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL8092987 | 0.80 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL11218447 | 0.78 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL8931021 | 0.78 | RAB9A (0.73) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL8108755 | 0.78 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL8102520 | 0.78 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1MAPTALDH1A1HTT | |
| SCHEMBL10909532 | 0.78 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174918-B1 | INHIBITING TUMOR CELL GROWTH SENSITIVE TO NAPHTHOQUINONE DERIVATIVE IN MAMMAL BY ADMINISTERING 2,3-DISUBSTITUTED NAPHTHOQUINONE COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-16 | — | — | US | disclosed |
| US-5789431-A | INHIBITING CELL TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1997030022-A1 | NAPHTHOQUINONE ANTITUMOR COMPOUND AND METHOD | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-08-21 | — | — | WO | disclosed |