Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGLRA1GLRBKCNK10KCNK18KCNK2KCNK3KCNK9
The experimentally established mechanism targets of Sevoflurane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sevoflurane SCHEMBL6053169 | 0.91 | — | — | |
| SCHEMBL24412818 | 0.83 | — | — | |
| SCHEMBL25453682 | 0.83 | — | — | |
| Sevoflurane SCHEMBL8643513 | 0.78 | CA1 (0.31) | CA1CA2CA9 | |
| SCHEMBL13555420 | 0.77 | — | — | |
| SCHEMBL1022174 | 0.77 | — | — | |
| SCHEMBL4732844 | 0.76 | CA1 (0.33) | CA1CA2CA9 | |
| SCHEMBL1023192 | 0.76 | CA1 (0.33) | CA1CA2CA9 | |
| SCHEMBL13555419 | 0.75 | — | — | |
| SCHEMBL4760088 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12024 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2025165991-A9 | BIOPOLYMERIC ANTI-ANTIBIOTICS AND METHODS FOR MAKING AND USING THE SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2026-05-21 | — | — | WO | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| EP-4731083-A1 | TRACKING THE LEVEL OF ANESTHESIA-MEDIATED UNCONSCIOUSNESS | Massachusetts Institute of Technology (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| EP-4157407-B1 | INHALER DEVICE FOR INHALABLE LIQUIDS | MEDICAL DEVELOPMENTS INTERNATIONAL LTD (AU) | 2026-03-25 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4698258-A1 | LOW INTERNAL RESISTANCE POLYMER PARTITIONED ANESTHETIC VAPORIZER SYSTEM AND METHOD | Rheos Medical Corp. (US) | 2026-02-25 | — | — | EP | claimed |
| US-20260048034-A1 | COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF DICARBOXYLIC ACID ESTERS, AND USES THEREOF | NEW FRONTIER LABS LLC (US) | 2026-02-19 | — | — | US | claimed |
| WO-1994023727-A1 | ANALGESIC ANAESTHETIC COMPOSITIONS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1994-10-27 | — | — | WO | claimed |
| WO-1994017016-A1 | DEUTERATED SEVOFLURANE AS AN INHALATIONAL ANESTHETIC | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1994-08-04 | — | — | WO | claimed |
| EP-0557658-A1 | Raman spectroscopy of respiratory gases | Hewlett-Packard Company (US) | 1993-09-01 | — | — | EP | claimed |
| EP-0341005-B1 | PROCESS FOR THE PRODUCTION OF FLUORINATED ETHERS | ANAQUEST, INC. (US) | 1993-07-28 | — | — | EP | claimed |
| EP-0535567-A1 | Liposomes containing volatile inhalation anaesthetics, their preparation and their use | B. Braun Melsungen AG (DE) | 1993-04-07 | — | — | EP | claimed |
| EP-0437689-A1 | A method for fluorodecarboxylation | Ohmeda Pharmaceutical Products Division Inc. (US) | 1991-07-24 | — | — | EP | claimed |
| US-4996371-A | Reacting halogenated aliphatic carboxylic acids with bromine trifluoride | BOC, INC. (US) | 1991-02-26 | — | — | US | claimed |
| EP-0341005-A1 | Process for the production of fluorinated ethers | ANAQUEST, INC. (US) | 1989-11-08 | — | — | EP | claimed |
| US-4874902-A | FLUORINATION WITH CHLORINE OR BROMINE TRIFLUORIDE | BOC, INC. (US) | 1989-10-17 | — | — | US | claimed |
| US-4874901-A | USING SODIUM OR POTASSIUM FLUORIDE | BOC, INC. (US) | 1989-10-17 | — | — | US | claimed |