SCHEMBL6192309

SCHEMBL6192309

CC(C)(C)OC(=O)NCc1ccc(C(O)c2cc(Cl)ccc2N)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.48
HDAC1 Q13547 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
MEN1 O00255 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NAMPT P43490 2/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
HTRA1 Q92743 3/20 0.39
IDO1 P14902 2/20 0.39
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6190141 0.91 GAA (0.48) GAAHDAC1L3MBTL1MEN1RAB9A
SCHEMBL6188262 0.89 CA2 (0.44) GAAMEN1KMT2ASMN1; SMN2NAMPT
SCHEMBL6188694 0.89 CTSL (0.41) GAAHDAC1IDO1LMNA
SCHEMBL8205220 0.88 CA1 (0.42) GAAMEN1KMT2ASMN1; SMN2CA1
SCHEMBL6191215 0.86 AAK1 (0.40) GAAMEN1RAB9AKMT2ASMN1; SMN2
SCHEMBL6188282 0.83 GAA (0.45) GAAHDAC1L3MBTL1MEN1RAB9A
SCHEMBL6189254 0.82 KCNA5 (0.41) GAAHDAC1MEN1KMT2ASMN1; SMN2
SCHEMBL6191209 0.81 AAK1 (0.33) GAAIDO1MAPT
SCHEMBL6185337 0.81 KDM4E (0.45) MEN1KMT2ASMN1; SMN2NAMPTCA1
SCHEMBL6191836 0.80 GAA (0.42) GAAHDAC1MEN1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0979227-B1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA PHARMACEUTICAL (JP) 2005-11-16 EP disclosed
US-6352982-B1 TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-05 US disclosed
CN-1252795-A 4, 1-benzoxazepine *, their analogs and their use as somatostatin agonists TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2000-05-10 CN disclosed
EP-0979227-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS Takeda Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
WO-1998047882-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-29 WO disclosed