Brofoxine

Brofoxine

SCHEMBL61925

CC1(C)OC(=O)Nc2ccc(Br)cc21

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PGR P06401 20/20 0.59
AR P10275 4/20 0.54
NR3C1 P04150 3/20 0.54
NR3C2 P08235 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Brofoxine SCHEMBL29710912 1.00 PGR (0.59) PGRARNR3C1NR3C2
Brofoxine SCHEMBL4166335 0.87 PGR (0.68) PGRARNR3C1NR3C2
SCHEMBL15210358 0.86 PGR (0.48) PGRARNR3C1NR3C2
SCHEMBL3870385 0.84 PGR (0.71) PGRARNR3C1NR3C2
SCHEMBL5516094 0.81 LMNA (0.42) PGRARNR3C1NR3C2
SCHEMBL3295805 0.81 PGR (0.60) PGRARNR3C1NR3C2
SCHEMBL3377467 0.81 PGR (0.60) PGRARNR3C1NR3C2
SCHEMBL28749684 0.81 PGR (0.50) PGR
SCHEMBL12649317 0.79 PGR (0.59) PGRARNR3C1NR3C2
SCHEMBL3380231 0.79 PGR (0.59) PGRARNR3C1NR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 444 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-8129523-B2 Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls WYETH LLC (US) 2012-03-06 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
US-20090220611-A1 Microparticles With Modified Release of At Least One Active Principle and Oral Pharmaceutical Form Comprising Same FLAMEL TECHNOLOGIES, S.A. (FR) 2009-09-03 US claimed
US-20090054663-A1 COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS WYETH (US) 2009-02-26 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20050272702-A1 Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls WYETH (US) 2005-12-08 US claimed
WO-2005105817-A2 COUPLING PROCESS FOR GENERATING REACTIVE BORON­ CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2­ CARBONITRILES TO PRODUCE BIARYLS WYETH (US) 2005-11-10 WO claimed
EP-1044023-B1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA LUITPOLD PHARM INC (US) 2005-05-25 EP claimed
EP-1221844-A2 SELECTIVE HERBICIDES BASED ON PYRIMIDINE-DERIVATIVES Bayer Aktiengesellschaft (DE) 2002-07-17 EP claimed
WO-2001024633-A2 SELECTIVE HERBICIDES BASED ON PYRIMIDINE-DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2001-04-12 WO claimed
US-6197764-B1 COMPLEX WITH FATTY ACID; THERAPY FOR PSYCHOLOGICAL DISORDERS PROTARGA, INC. 2001-03-06 US claimed
EP-1044023-A1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA Protarga Inc. (US) 2000-10-18 EP claimed
US-5955459-A Fatty acid-antipsychotic compositions and uses thereof NEUROMEDICA, INC. (US) 1999-09-21 US claimed
WO-1999026661-A1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA PROTARGA INC. (US) 1999-06-03 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054663-A1 COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS BOLA2; BOLA2B, BRI3BP, BROX PGR 1401/4885AR 3276/4885NR3C1 2069/4885
US-20050272702-A1 Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls BOLA2; BOLA2B, BRI3BP, BROX PGR 1401/4885AR 3276/4885NR3C1 2069/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.