Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193808 | 0.83 | MAT2A (0.35) | MAT2AALDH1A1KMT2ALMNA | |
| SCHEMBL5093112 | 0.80 | MAT2A (0.40) | MAT2AALDH1A1KMT2ALMNA | |
| SCHEMBL6193055 | 0.77 | PDE10A (0.40) | MAT2AALDH1A1LMNACYP1A2POLB | |
| SCHEMBL5089800 | 0.75 | GLA (0.32) | KMT2A | |
| SCHEMBL5094657 | 0.74 | MAT2A (0.38) | MAT2AALDH1A1LMNACYP1A2POLB | |
| SCHEMBL6193804 | 0.71 | MTNR1A (0.44) | ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5093132 | 0.70 | MAT2A (0.34) | MAT2AALDH1A1KMT2ALMNA | |
| SCHEMBL5767358 | 0.70 | MAT2A (0.41) | MAT2AALDH1A1LMNAPOLB | |
| SCHEMBL5094654 | 0.68 | ELANE (0.32) | MAT2AALDH1A1KMT2ALMNA | |
| SCHEMBL5101431 | 0.68 | DNMT1 (0.38) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517909-A2 | NOVEL TETRACYCLIC ARYLCARBONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Suven Life Sciences Limited (IN) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000205-A2 | NOVEL TETRACYCLIC ARYLCARBONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2003-12-31 | — | — | WO | disclosed |