Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193055 | 0.82 | PDE10A (0.40) | MAT2ATACR1LMNAALDH1A1MAPT | |
| SCHEMBL6193804 | 0.82 | MTNR1A (0.44) | ALDH1A1 | |
| SCHEMBL5094657 | 0.81 | MAT2A (0.38) | MAT2ATACR1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5093108 | 0.79 | MAT2A (0.37) | MAT2ATACR1LMNAALDH1A1KMT2A | |
| SCHEMBL5767358 | 0.79 | MAT2A (0.41) | MAT2ALMNAALDH1A1MAPT | |
| SCHEMBL6193808 | 0.70 | MAT2A (0.35) | MAT2ALMNAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6193060 | 0.70 | MAT2A (0.37) | MAT2ALMNAALDH1A1KMT2A | |
| SCHEMBL5101367 | 0.69 | HTR6 (0.40) | MAT2ALMNAALDH1A1MAPT | |
| SCHEMBL5089797 | 0.68 | HTR6 (0.41) | LMNAMAPT | |
| SCHEMBL5767360 | 0.67 | MAT2A (0.42) | MAT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317035-B2 | Tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-01-08 | — | — | US | claimed |