Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193694 | 0.80 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16058121 | 0.77 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16403235 | 0.75 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16058346 | 0.74 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5186125 | 0.69 | HSD17B10 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5221777 | 0.68 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3187893 | 0.68 | LMNA (0.39) | ALDH1A1CYP1A2CYP2C9HPGDUSP2 | |
| SCHEMBL16403233 | 0.67 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16058120 | 0.67 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16057603 | 0.66 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3021879-A2 | METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH | Cayman Chemical Company, Incorporated (US) | 2016-05-25 | — | — | EP | disclosed |
| EP-2989098-A2 | LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS | Cayman Chemical Company, Incorporated (US) | 2016-03-02 | — | — | EP | disclosed |
| WO-2015009991-A2 | METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH | CAYMAN CHEMICAL COMPANY, INC. (US) | 2015-01-22 | — | — | WO | disclosed |
| WO-2014144584-A2 | LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS | CAYMAN CHEMICAL COMPANY, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-1558602-A2 | 2-PYRROLIDONES AS EP4 RECEPTOR AGONISTS | MERCK FROSST CANADA INC. (CA) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037786-A2 | 2-PYRROLIDONES AS EP4 RECEPTOR AGONISTS | MERCK FROSST CANADA & CO. (CA) | 2004-05-06 | — | — | WO | disclosed |