Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184629 | 0.88 | HSD17B10 (0.38) | HSD17B10ALDH1A1CYP2C9CYP3A4HPGD | |
| SCHEMBL16058346 | 0.74 | ALDH1A1 (0.46) | HSD17B10ALDH1A1CYP2C9CYP3A4HPGD | |
| SCHEMBL5429111 | 0.72 | LMNA (0.36) | HSD17B10ALDH1A1CYP1A2TP53PKM | |
| SCHEMBL5221777 | 0.71 | ALDH1A1 (0.40) | HSD17B10ALDH1A1CYP2C9CYP3A4HPGD | |
| SCHEMBL3187893 | 0.71 | LMNA (0.39) | HSD17B10ALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL5175085 | 0.71 | LDHA (0.38) | HSD17B10ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL5429108 | 0.70 | LRRK2 (0.43) | HSD17B10ALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL6193699 | 0.69 | ALDH1A1 (0.40) | HSD17B10ALDH1A1CYP2C9CYP3A4HPGD | |
| SCHEMBL5220855 | 0.68 | CTSD (0.50) | HSD17B10ALDH1A1CYP2C9CYP3A4HPGD | |
| SCHEMBL5434946 | 0.68 | NPC1 (0.43) | ALDH1A1CYP2C9CYP3A4HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |