Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLB1 | P16278 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196007 | 0.84 | KDM4E (0.41) | KDM4ELMNAAPPMAOAMAOB | |
| SCHEMBL6196974 | 0.84 | KDM4E (0.49) | KDM4ELMNATEAD4APPMAOA | |
| SCHEMBL6195630 | 0.84 | KDM4E (0.41) | KDM4ELMNATEAD4APPMAOA | |
| SCHEMBL6195700 | 0.83 | LMNA (0.43) | KDM4ELMNATEAD4APPMAOA | |
| SCHEMBL6196526 | 0.80 | KDM4E (0.41) | KDM4ELMNAAPPFTO | |
| SCHEMBL6198108 | 0.80 | TOP2A (0.43) | KDM4ELMNAAPPMAOAMAOB | |
| SCHEMBL6195385 | 0.79 | APP (0.56) | KDM4ELMNAAPPTHRB | |
| SCHEMBL6198121 | 0.76 | NQO1 (0.44) | KDM4ELMNATEAD4CYP1A2 | |
| SCHEMBL6193498 | 0.74 | ALDH1A1 (0.44) | CYP2C19CYP1A2MAPK1 | |
| SCHEMBL6197598 | 0.73 | LMNA (0.53) | LMNAMAOAMAOBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |