Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195630 | 0.84 | KDM4E (0.41) | KDM4ELMNAFTOAPPBRD4 | |
| SCHEMBL6196974 | 0.84 | KDM4E (0.49) | KDM4ELMNAFTOAPPBRD4 | |
| SCHEMBL6194369 | 0.84 | KDM4E (0.41) | KDM4ELMNAFTOAPPMAOA | |
| SCHEMBL6195700 | 0.83 | LMNA (0.43) | KDM4ELMNANQO1FTOAPP | |
| SCHEMBL6196526 | 0.80 | KDM4E (0.41) | KDM4ELMNAFTOAPP | |
| SCHEMBL6198108 | 0.80 | TOP2A (0.43) | KDM4ELMNAFTOAPPBRD4 | |
| SCHEMBL6195385 | 0.79 | APP (0.56) | KDM4ELMNAAPPHPGD | |
| SCHEMBL6198121 | 0.76 | NQO1 (0.44) | KDM4ELMNANQO1TSHRHIF1A | |
| SCHEMBL6193498 | 0.74 | ALDH1A1 (0.44) | MAPK1HPGD | |
| SCHEMBL6196338 | 0.73 | LMNA (0.53) | LMNAMAOAMAOBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |