Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260656 | 0.87 | SLC6A2 (0.45) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL6192035 | 0.87 | SLC6A2 (0.45) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL6193617 | 0.78 | HTR6 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL3634855 | 0.78 | HTR6 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL4605132 | 0.77 | ADRB3 (0.46) | SLC6A2SLC6A4KCNH2SLC6A3HTR6 | |
| SCHEMBL6185597 | 0.72 | HRH3 (0.39) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL5901549 | 0.71 | POLB (0.60) | — | |
| SCHEMBL5995472 | 0.70 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL9330136 | 0.69 | HTR2A (0.42) | SLC6A2SLC6A4KCNH2CYP2D6HTR6 | |
| SCHEMBL16825719 | 0.68 | ALDH1A1 (0.46) | SLC6A2SLC6A4KCNH2SLC6A3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583751-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES | CV THERAPEUTICS, INC. (US) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004069818-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES | CV THERAPEUTICS INC. (US) | 2004-08-19 | — | — | WO | disclosed |