Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193617 | 1.00 | HTR6 (0.48) | HTR6HTR3AHTR3EHTR3BADRB1 | |
| SCHEMBL6192035 | 0.84 | SLC6A2 (0.45) | HTR6SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL6260656 | 0.84 | SLC6A2 (0.45) | HTR6SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL11464652 | 0.82 | KMT2A (0.44) | MAPTKMT2AADRA2AADRA2BADRA2C | |
| SCHEMBL5746091 | 0.81 | KMT2A (0.40) | SLC6A2SLC6A4SLC6A3MAPTKMT2A | |
| SCHEMBL6195075 | 0.78 | SLC6A2 (0.41) | HTR6SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL4605132 | 0.77 | ADRB3 (0.46) | HTR6ADRB1DRD2DRD3SLC6A2 | |
| SCHEMBL2329647 | 0.76 | LMNA (0.57) | ADRB1DRD2CYP2C19DRD3SLC6A2 | |
| SCHEMBL18050256 | 0.74 | LMNA (0.51) | HTR6HTR3AHTR3EHTR3BADRB1 | |
| SCHEMBL335012 | 0.74 | SLC6A2 (0.54) | HTR6HTR3AHTR3EHTR3BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155697-A1 | SUBSTITUTED PIPERAZINES | Auspex Pharmaceuticals Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008157240-A1 | SUBSTITUTED PIPERAZINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1406898-A1 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008411-A1 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2003-01-30 | — | — | WO | disclosed |