Pramoxine

Pramoxine

SCHEMBL26020

CCCCOc1ccc(OCCCN2CCOCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
HRH3 Q9Y5N1 5/20 1.00
MAPK1 P28482 2/20 1.00
CYP1A2 P05177 1/20 1.00
CHRM2 P08172 1/20 1.00
CHRM1 P11229 1/20 1.00
HTR2A P28223 1/20 1.00
SCN1A P35498 1/20 1.00
HTR2B P41595 1/20 1.00
KCNH2 Q12809 1/20 1.00
SCN2A Q99250 1/20 1.00
SIGMAR1 Q99720 1/20 1.00
SCN3A Q9NY46 1/20 1.00
LMNA P02545 3/20 0.97
USP2 O75604 2/20 0.97
THRB P10828 2/20 0.67
MAPT P10636 1/20 0.67
KMT2A Q03164 1/20 0.67
TSHR P16473 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pramoxine SCHEMBL180542 0.98 LMNA (1.00) ALDH1A1HRH3MAPK1CYP1A2CHRM2
Pramoxine SCHEMBL4435138 0.97 ALDH1A1 (0.94) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL23804878 0.95 HRH3 (0.91) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL29508217 0.93 ALDH1A1 (0.88) ALDH1A1HRH3MAPK1CYP1A2CHRM2
Pramoxine SCHEMBL29048599 0.91 ALDH1A1 (0.83) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL29508145 0.90 ALDH1A1 (0.82) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL29508184 0.90 ALDH1A1 (0.81) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL13186317 0.89 HRH3 (0.80) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL171264 0.89 HRH3 (0.79) ALDH1A1HRH3MAPK1CYP1A2CHRM2
SCHEMBL23804879 0.89 HRH3 (0.79) ALDH1A1HRH3MAPK1CYP1A2CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11296 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115156-A1 INJECTABLE COMPOSITION INCLUDING HYDROGEL CONTAINING ANESTHETIC AGENT UNIV KOREA RES & BUS FOUND (KR) 2026-04-30 US claimed
EP-4694866-A1 SUSTAINED RELEASE STABLE EMULSION PHARMACEUTICAL FORMULATIONS Insitu Biologics, Inc. (US) 2026-02-18 EP claimed
US-20260027069-A1 Compositions Comprising Pramoxine and Diphenydramine for Treatment of Skin Conditions CRESTLINE DIRECT FINANCE, L.P., AS AGENT 2026-01-29 US claimed
US-20260007753-A1 DERMAL SKIN PROTECTANT AND CARRIER INSPIRED MAT STRATEGIES LLC (US) 2026-01-08 US claimed
WO-2025235864-A1 COATED NEEDLE ADMINISTRATION SYSTEMS EVOLUS, INC. (US) 2025-11-13 WO claimed
US-20250319103-A1 COMPOSITIONS FOR TREATMENT OF ANAL GLAND DISEASE CRESTLINE DIRECT FINANCE, L.P., AS AGENT 2025-10-16 US claimed
US-20250319025-A9 COMPOSITIONS COMPRISING MODIFIED PHOSPHOLIPIDS AND USES THEREOF THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-16 US claimed
US-20250319047-A1 ANTIMICROBIAL TREATMENT AND PREVENTION BY PERILLYL ALCOHOL AND DERIVATIVES ZAYAS RIVERA JOSE (US) 2025-10-16 US claimed
US-12419619-B2 Aspiration device YALE UNIVERSITY (US) 2025-09-23 US claimed
US-12419959-B2 Dermal skin protectant and carrier Inspired Material Strategies, LLC (US) 2025-09-23 US claimed
EP-0471135-A2 Compositions, medicaments and methods for the promotion of hair growth Hallam, Kenneth M. (US) 1992-02-19 EP claimed
EP-0454617-A1 Treatment of sinus headache WARNER-LAMBERT COMPANY (US) 1991-10-30 EP claimed
US-5057500-A TREATMENT OF PRURITIS WITH ESTERS AND AMIDES DERMATOLOGIC RESEARCH CORPORATION (US) 1991-10-15 US claimed
WO-1991012010-A1 TREATMENT OF PRURITIS WITH ESTERS AND AMIDES DERMATOLOGIC RESEARCH CORPORATION (US) 1991-08-22 WO claimed
US-5002974-A Oil phase with nonionic surfactant, water phase with thickener for emulsions for skin WARNER-LAMBERT CO. (US) 1991-03-26 US claimed
EP-0413528-A1 Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use Yu, Ruey J., Dr. (US) 1991-02-20 EP claimed
EP-0391033-A2 Retinal, derivatives and their therapeutic use Yu, Ruey J., Dr. (US) 1990-10-10 EP claimed
US-4937078-A ENCAPSULATED; TOPICAL APPLICATION MEZEI ASSOCIATES LIMITED (CA) 1990-06-26 US claimed
EP-0338173-A1 Ionic dressing for topical administration of drugs to wounds and burns RICOH KYOSAN INC. (JP) 1989-10-25 EP claimed
EP-0336901-A2 Anesthetic skin moisturizing composition and method of preparing same WARNER-LAMBERT COMPANY (US) 1989-10-11 EP claimed