Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 13/20 | 0.39 |
| ▸ | CTSK | P43235 | 11/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836398 | 0.71 | CTSK (0.45) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL4837541 | 0.70 | CTSK (0.49) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL4835405 | 0.70 | CTSK (0.49) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL4835423 | 0.70 | CTSK (0.49) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL4836327 | 0.70 | CTSS (0.69) | CTSLCTSSCTSKCTSB | |
| SCHEMBL29056863 | 0.64 | CTSL (0.51) | CTSLCTSSCTSKCTSB | |
| SCHEMBL23276791 | 0.62 | CTSL (0.39) | CTSLCTSSCTSKCTSB | |
| SCHEMBL23070898 | 0.62 | CTSL (0.39) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL12400792 | 0.62 | CTSS (0.66) | CTSLCTSSCTSKCTSB | |
| SCHEMBL29818831 | 0.61 | CTSL (0.36) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606258-A1 | CATHEPSIN S INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004083182-A1 | CATHEPSIN S INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |