Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930784 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL212969 | 0.83 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL5133527 | 0.81 | PSIP1 (0.52) | PTGS2PTGS1NPC1PTGDR2MMP2 | |
| SCHEMBL5049079 | 0.81 | PSIP1 (0.52) | PTGS2PTGS1NPC1PTGDR2MMP2 | |
| SCHEMBL8993420 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL198600 | 0.79 | PSIP1 (0.58) | NPC1PTGDR2PSEN1PSEN2APH1B | |
| Sulfamide SCHEMBL4638163 | 0.76 | PTGS2 (0.65) | PTGS2PTGS1NPC1 | |
| SCHEMBL215434 | 0.73 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL6045043 | 0.71 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL8384120 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1505962-A2 | MONOTHERAPY FOR THE TREATMENT OF PARKINSON'S DISEASE WITH CYCLOOXYGENASE-2 (COX 2) INHIBITOR(S) | Pharmacia Corporation (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003088959-A2 | TREATMENT OF PARKINSON'S DISEASE WITH CYCLOOXYGENASE-2 (COX 2) INHIBITOR(S) | PHARMACIA CORPORATION (US) | 2003-10-30 | — | — | WO | disclosed |