Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304817 | 0.83 | PDE5A (0.56) | KMT2AMEN1POLBPDE5AGBA1 | |
| SCHEMBL6199066 | 0.83 | KMT2A (0.58) | KMT2APOLBPDE5ARXFP1RAB9A | |
| SCHEMBL6197039 | 0.83 | KMT2A (0.53) | KMT2AMEN1POLBPDE5ARXFP1 | |
| SCHEMBL6201352 | 0.82 | KMT2A (0.51) | KMT2AMEN1POLBPDE5ARXFP1 | |
| SCHEMBL6194105 | 0.78 | KMT2A (0.45) | KMT2AMEN1POLBPDE5ARXFP1 | |
| SCHEMBL6332500 | 0.77 | KMT2A (0.52) | KMT2AMEN1POLBPDE5ARXFP1 | |
| SCHEMBL7002737 | 0.76 | KMT2A (0.53) | KMT2AMEN1POLBPDE5ARXFP1 | |
| SCHEMBL5875796 | 0.76 | MEN1 (0.60) | KMT2AMEN1POLBTSHRLMNA | |
| SCHEMBL4565717 | 0.75 | TERT (0.56) | KMT2AMEN1POLBPDE5ACA12 | |
| SCHEMBL6194610 | 0.74 | KMT2A (0.53) | KMT2AMEN1POLBPDE5ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |