Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | PDE5A | O76074 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196595 | 0.87 | PDE5A (0.55) | KMT2APDE5AKDM4ERXFP1GAA | |
| SCHEMBL6197110 | 0.86 | KMT2A (0.54) | KMT2APDE5AKDM4ERXFP1NPC1 | |
| SCHEMBL6197854 | 0.83 | KMT2A (0.55) | KMT2APDE5AKDM4ERXFP1RAB9A | |
| SCHEMBL6197903 | 0.83 | PDE5A (0.54) | KMT2APDE5AKDM4ERXFP1GAA | |
| SCHEMBL6447569 | 0.78 | PDE5A (0.78) | KMT2APDE5AKDM4ERXFP1 | |
| SCHEMBL6443603 | 0.78 | PDE5A (0.70) | KMT2APDE5AKDM4ERXFP1NPC1 | |
| SCHEMBL7003161 | 0.76 | PDE5A (0.62) | KMT2APDE5AKDM4ERXFP1NPC1 | |
| SCHEMBL6996946 | 0.76 | PDE5A (0.72) | KMT2APDE5AKDM4ERXFP1PKM | |
| SCHEMBL6999379 | 0.75 | PDE5A (0.69) | KMT2APDE5AKDM4ERXFP1PKM | |
| SCHEMBL6443282 | 0.75 | PDE5A (0.63) | KMT2APDE5AKDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |