Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18682734 | 0.81 | CCR1 (0.52) | CCR1CCR5CCR8HDAC6PDE10A | |
| SCHEMBL4033509 | 0.80 | CCR1 (0.43) | CCR1CCR5CCR8HDAC6PDE10A | |
| SCHEMBL30361378 | 0.80 | CCR1 (0.43) | CCR1CCR5CCR8HDAC6PDE10A | |
| Hydrochloric Acid SCHEMBL247415 | 0.78 | CCR1 (0.41) | CCR1CCR5CCR8HDAC6PDE10A | |
| SCHEMBL1639271 | 0.77 | GBA1 (0.39) | MAPTRAB9AKDM4EKMT2AALDH1A1 | |
| SCHEMBL31212506 | 0.77 | CA12 (0.37) | ADRA2AADRA2BADRA2C | |
| SCHEMBL13680812 | 0.77 | ESR1 (0.42) | — | |
| SCHEMBL13680819 | 0.77 | DAO (0.46) | DAOALDH1A1 | |
| SCHEMBL22151010 | 0.77 | CA12 (0.37) | ADRA2AADRA2BADRA2C | |
| SCHEMBL13680816 | 0.77 | DAO (0.35) | DAOKDM4EALDH1A1PLAUADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066304-B1 | MACROLIDE LHRH ANTAGONISTS | ABBOTT LAB (US) | 2005-02-23 | — | — | EP | disclosed |
| CN-1307584-A | Macrolide LHRH antagonists | ABBOTT LAB (US) | 2001-08-08 | — | — | CN | disclosed |
| EP-1066304-A1 | MACROLIDE LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999050275-A2 | MACROLIDE LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 1999-10-07 | — | — | WO | disclosed |
| US-5955440-A | 3'-N-DESMETHYL-3'-N-SUBSTITUTED-6-O-METHYL-11-DEOXY-11,12-CYCL IC CARBAMATE ERYTHROMYCIN A DERIVATIVES | ABBOTT LABORATORIES (US) | 1999-09-21 | — | — | US | disclosed |
| US-5808101-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5710288-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-01-20 | — | — | US | disclosed |