Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 8/20 | 0.37 |
| ▸ | METAP2 | P50579 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6194058 | 0.81 | NOS1 (0.43) | MAPTNOS1METAP2DYRK1AKDM4E | |
| SCHEMBL6197375 | 0.81 | MAPT (0.45) | MAPTNOS1METAP2DYRK1AKDM4E | |
| SCHEMBL6198760 | 0.81 | NOS1 (0.43) | MAPTNOS1METAP2DYRK1AKDM4E | |
| SCHEMBL6195962 | 0.78 | MAPT (0.38) | MAPTNOS1KDM4EHTTRET | |
| SCHEMBL6197138 | 0.78 | MAPT (0.38) | MAPTNOS1METAP2DYRK1AKDM4E | |
| SCHEMBL6196219 | 0.78 | MAPT (0.38) | MAPTNOS1DYRK1AHTTAURKA | |
| SCHEMBL6196073 | 0.78 | MAPT (0.38) | MAPTNOS1METAP2DYRK1AKDM4E | |
| SCHEMBL2048983 | 0.71 | MAPT (0.41) | MAPTNOS1KDM4EMEN1KMT2A | |
| SCHEMBL19303388 | 0.70 | GPR3 (0.43) | MAPTKDM4ECYP1A2HPGDSMN1; SMN2 | |
| SCHEMBL276444 | 0.66 | HSD17B10 (0.53) | MAPTNOS1METAP2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |