SCHEMBL2048983

SCHEMBL2048983

c1cc2c(ccc3cn[nH]c32)s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.41
NOS1 P29475 3/20 0.39
HTR2C P28335 2/20 0.36
HTR2A P28223 1/20 0.36
LMNA P02545 1/20 0.35
ADRA2A P08913 1/20 0.35
ADRA2B P18089 1/20 0.35
KDM4E B2RXH2 4/20 0.34
HPGD P15428 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
PLK4 O00444 1/20 0.34
CHEK1 O14757 1/20 0.34
AURKA O14965 1/20 0.34
DAPK3 O43293 1/20 0.34
MAP4K4 O95819 1/20 0.34
CSF1R P07333 1/20 0.34
RET P07949 1/20 0.34
FGFR1 P11362 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20866826 0.77 ADRA2A (0.49) MAPTNOS1LMNAADRA2AADRA2B
SCHEMBL12469544 0.73 MAPT (0.43) MAPTNOS1KDM4EHPGDTDP1
SCHEMBL4913293 0.73 DYRK1A (0.38) MAPTNOS1HTR2CLMNATDP1
SCHEMBL6199102 0.71 MAPT (0.39) MAPTNOS1KDM4EHPGDTDP1
SCHEMBL6198760 0.70 NOS1 (0.43) MAPTNOS1KDM4EHPGDTDP1
SCHEMBL6194058 0.70 NOS1 (0.43) MAPTNOS1KDM4EHPGDTDP1
SCHEMBL6197375 0.70 MAPT (0.45) MAPTNOS1KDM4EHPGDTDP1
SCHEMBL17897161 0.69 TNF (0.37) MAPTHTR2CHTR2ALMNAADRA2A
SCHEMBL276444 0.68 HSD17B10 (0.53) MAPTNOS1KDM4EHPGDTDP1
SCHEMBL10655958 0.68 MAPT (0.46) MAPTNOS1KDM4EHPGDTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2336315-B1 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION AS (DK) 2017-07-19 EP claimed
EP-2336315-A2 Enzymatic encoding methods for efficient synthesis of large libraries Nuevolution A/S (DK) 2011-06-22 EP claimed
EP-3360578-B1 COMPOSITE GRANULATED PRODUCT INCLUDING SUGAR OR SUGAR ALCOHOL, SWELLING BINDER, DISINTEGRATING AGENT AND HIGHLY ABSORBENT EXCIPIENT, AND METHOD FOR MANUFACTURING COMPOSITE GRANULATED PRODUCT DAIDO CHEMICAL CORP (JP) 2024-12-11 EP disclosed
US-11702652-B2 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION A/S (DK) 2023-07-18 US disclosed
EP-3238711-B1 BASE FOR SOLID DISPERSION, PRODUCTION METHOD FOR SOLID DISPERSION USING SAME, AND SOLID DISPERSION MITSUBISHI CHEM CORP (JP) 2023-07-12 EP disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3305900-B1 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES NUEVOLUTION AS (DK) 2021-07-21 EP disclosed
US-20200216836-A1 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES NUEVOLUTION A/S (DK) 2020-07-09 US disclosed
US-10632074-B2 Composite granulated product including sugar or sugar alcohol, swelling binder, disintegrating agent and highly absorbent excipient, and method for manufacturing composite granulated product DAIDO CHEMICAL CORPORATION (JP) 2020-04-28 US disclosed
CN-106232144-B Solid dispersion 武田药品工业株式会社 2019-12-06 CN disclosed
US-20080145431-A1 Medicinal Composition and Process for Producing the Same EISAI R&D MANAGEMENT CO., LTD. (JP) 2008-06-19 US disclosed
US-20080063710-A1 Rapidly Disintegrating Tablet and Production Method Thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2008-03-13 US disclosed
EP-1839650-A1 QUICK DISINTEGRATION TABLET AND METHOD OF PRODUCING THE SAME Eisai R&D Management Co., Ltd. (JP) 2007-10-03 EP disclosed
EP-1834624-A1 MEDICINAL COMPOSITION AND PROCESS FOR PRODUCING THE SAME Eisai R&D Management Co., Ltd. (JP) 2007-09-19 EP disclosed
WO-2007062664-A2 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES NUEVOLUTION A/S (DK) 2007-06-07 WO disclosed
US-20060151899-A1 Process for producing drug ultramicroparticle and apparatus therefor EISAI R&D MANAGEMENT CO., LTD. (JP) 2006-07-13 US disclosed
EP-1652515-A1 PROCESS FOR PRODUCING DRUG ULTRAMICROPARTICLE AND APPARATUS THEREFOR Eisai Co., Ltd. (JP) 2006-05-03 EP disclosed
US-20030185878-A1 Process for producing phospholipid-containing drug TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2003-10-02 US disclosed
EP-1293197-A1 PROCESS FOR PRODUCING PHOSPHOLIPID-CONTAINING DRUGS Takeda Chemical Industries, Ltd. (JP) 2003-03-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030185878-A1 Process for producing phospholipid-containing drug PHOSPHO1, PLTP, PTDSS2 MAPT 1129/4885NOS1 1624/4885HTR2C 4060/4885
US-10632074-B2 Composite granulated product including sugar or sugar alcohol, swelling binder, disintegrating agent and highly absorbent excipient, and method for manufacturing composite granulated product SORD, STT3B, DDOST MAPT 1360/4885NOS1 2435/4885HTR2C 3204/4885
US-20080145431-A1 Medicinal Composition and Process for Producing the Same RPLP2, MYD88, EIF4G2 MAPT 802/4885NOS1 608/4885HTR2C 3139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.