Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196542 | 0.85 | KMT2A (0.33) | IDO1TDO2TEAD4KDM4EALDH1A1 | |
| SCHEMBL6199826 | 0.81 | UGT2B7 (0.37) | TEAD4SLC6A2SLC6A4KDM4EMAPT | |
| SCHEMBL6198019 | 0.80 | SMN1; SMN2 (0.45) | SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL6198424 | 0.78 | SMN1; SMN2 (0.42) | TEAD4SLC6A2SLC6A4KDM4EALDH1A1 | |
| SCHEMBL6195639 | 0.78 | KDM4E (0.35) | CES2CES1IDO1TDO2TEAD4 | |
| SCHEMBL6196517 | 0.77 | FPR2 (0.33) | TEAD4KDM4E | |
| SCHEMBL6196493 | 0.77 | KDM4E (0.34) | IDO1TDO2KDM4EALDH1A1LMNA | |
| SCHEMBL6193968 | 0.75 | TSHR (0.47) | GAAMAPT | |
| Alcohol SCHEMBL8928372 | 0.75 | KDM4E (0.36) | CES2CES1IDO1TDO2TEAD4 | |
| SCHEMBL6198566 | 0.74 | KDM4E (0.37) | KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |