Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 6/20 | 0.33 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | KDM6A | O15550 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195639 | 0.96 | KDM4E (0.35) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6198566 | 0.84 | KDM4E (0.37) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6196542 | 0.79 | KMT2A (0.33) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6195293 | 0.78 | KDM4E (0.41) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6198278 | 0.77 | SMN1; SMN2 (0.45) | HTTSMN1; SMN2 | |
| SCHEMBL6199262 | 0.75 | CES2 (0.35) | KDM4ETEAD4SLC6A2SLC6A4IDO1 | |
| SCHEMBL6197600 | 0.74 | KDM4E (0.37) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6196693 | 0.73 | MAPT (0.35) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6198088 | 0.73 | KMT2A (0.33) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6199826 | 0.72 | UGT2B7 (0.37) | KDM4ETP53CYP2D6HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |