Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CES2 | O00748 | 1/20 | 0.60 |
| ▸ | CES1 | P23141 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224695 | 1.00 | RAB9A (1.00) | RAB9ANPC1L3MBTL1MAPTCES2 | |
| SCHEMBL1753283 | 0.90 | RAB9A (0.85) | RAB9ANPC1L3MBTL1MAPTCES2 | |
| SCHEMBL5218244 | 0.90 | NPC1 (0.81) | RAB9ANPC1L3MBTL1MAPTCES2 | |
| SCHEMBL6204395 | 0.85 | RAB9A (0.74) | RAB9ANPC1L3MBTL1MAPTKMT2A | |
| SCHEMBL9262872 | 0.85 | RAB9A (0.74) | RAB9ANPC1L3MBTL1MAPTKMT2A | |
| SCHEMBL5041185 | 0.85 | RAB9A (0.74) | RAB9ANPC1L3MBTL1MAPTKMT2A | |
| SCHEMBL10649146 | 0.83 | RAB9A (1.00) | RAB9ANPC1L3MBTL1MAPTKMT2A | |
| SCHEMBL12637601 | 0.83 | NPC1 (0.71) | RAB9ANPC1L3MBTL1MAPTKMT2A | |
| SCHEMBL1393818 | 0.83 | L3MBTL1 (0.76) | RAB9ANPC1L3MBTL1MAPTKMT2A | |
| SCHEMBL28629860 | 0.83 | NPC1 (0.71) | RAB9ANPC1L3MBTL1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |