Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014140 | 0.89 | GAA (0.57) | GAALMNASMN1; SMN2SCDALDH1A1 | |
| SCHEMBL23014314 | 0.86 | GAA (0.60) | GAALMNASCDALDH1A1POLB | |
| SCHEMBL23014481 | 0.83 | MAPT (0.53) | GAALMNASMN1; SMN2SCDALDH1A1 | |
| SCHEMBL15401635 | 0.78 | LMNA (0.55) | GAALMNASMN1; SMN2SCDALDH1A1 | |
| SCHEMBL4007613 | 0.78 | GAA (0.62) | GAALMNASMN1; SMN2ALDH1A1KCNK3 | |
| SCHEMBL2888751 | 0.78 | LMNA (0.66) | GAALMNASMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL30748278 | 0.78 | LMNA (0.66) | GAALMNASMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL16711830 | 0.77 | LMNA (0.47) | GAALMNASMN1; SMN2SCDALDH1A1 | |
| SCHEMBL30365971 | 0.74 | LMNA (0.60) | GAALMNASMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL17713026 | 0.74 | LMNA (0.52) | GAALMNASMN1; SMN2KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |