Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200742 | 0.72 | ADRA1A (0.36) | MEN1KMT2AADORA3POLBMAPT | |
| SCHEMBL6200139 | 0.68 | ADORA3 (0.46) | MEN1KMT2AADORA3POLBSLC6A3 | |
| SCHEMBL6199441 | 0.68 | MEN1 (0.44) | MEN1KMT2AADORA3NPEPPSCRHBP | |
| SCHEMBL8440174 | 0.65 | TSHR (0.61) | MEN1KMT2AADORA3MAPT | |
| SCHEMBL7160123 | 0.64 | ADORA3 (0.85) | MEN1KMT2AADORA3POLBMAPT | |
| SCHEMBL306161 | 0.64 | POLB (0.81) | MEN1KMT2APOLBALDH1A1PKM | |
| Iodide SCHEMBL22235392 | 0.63 | POLB (0.78) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL6196597 | 0.61 | ADORA3 (0.48) | MEN1KMT2AADORA3NPEPPSPOLB | |
| SCHEMBL9064391 | 0.61 | ADORA3 (0.78) | MEN1KMT2AADORA3POLBMAPT | |
| SCHEMBL7160127 | 0.61 | ADORA3 (0.78) | MEN1KMT2AADORA3POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |