Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MYLK | Q15746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337661 | 0.72 | ADRA1A (0.36) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL6197215 | 0.72 | ADRA1A (0.36) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL6200141 | 0.72 | MEN1 (0.51) | MEN1KMT2AADORA3MAPTPOLB | |
| SCHEMBL7240694 | 0.69 | ADRA1A (0.41) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL6217186 | 0.68 | ADRA1A (0.37) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL6196130 | 0.68 | SMN1; SMN2 (0.40) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL7953512 | 0.68 | SMN1; SMN2 (0.40) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL6782795 | 0.68 | ADRA1A (0.36) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL7243873 | 0.67 | ADRA1A (0.39) | ADRA1AMEN1KMT2AADORA3CACNA1D | |
| SCHEMBL7236540 | 0.66 | ADRA1A (0.37) | ADRA1AMEN1KMT2AADORA3CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |