Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040570 | 0.84 | ALOX15 (0.57) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL6200880 | 0.78 | CDK1 (0.48) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL29865409 | 0.74 | KDM4E (0.58) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL5359001 | 0.74 | ALOX15 (0.57) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL4040550 | 0.74 | KDM4E (0.58) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL4040538 | 0.72 | CDK1 (0.54) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL4043989 | 0.71 | CDK1 (0.56) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL5356682 | 0.70 | CDK1 (0.55) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL1654435 | 0.70 | ALDH1A1 (0.56) | CDK1CCNB1ALOX15HPGDSMN1; SMN2 | |
| SCHEMBL31501858 | 0.69 | RAB9A (0.58) | CDK1CCNB1PTGESALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325008-B1 | PIPERAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2005-10-05 | — | — | EP | disclosed |