Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | MGAM | O43451 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | SI | P14410 | 4/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28743174 | 0.84 | HPGD (0.62) | HPGDGAALMNANPSR1ALDH1A1 | |
| SCHEMBL6200667 | 0.83 | TSHR (0.63) | HPGDMGAMGAASIMGAM2 | |
| SCHEMBL1754732 | 0.74 | KMT2A (0.71) | HPGDLMNAL3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL27895847 | 0.74 | MGAM (0.62) | HPGDMGAMGAASIMGAM2 | |
| SCHEMBL1238318 | 0.74 | TSHR (0.63) | HPGDLMNAALDH1A1KDM4ECRHBP | |
| SCHEMBL9326756 | 0.74 | HPGD (0.50) | HPGDLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL8436216 | 0.74 | L3MBTL1 (0.71) | HPGDGAALMNAL3MBTL1NPSR1 | |
| SCHEMBL28963600 | 0.74 | HPGD (0.50) | HPGDLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9066674 | 0.74 | ATM (0.74) | HPGDLMNAL3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL6201780 | 0.73 | LMNA (0.65) | HPGDMGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |