Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | GGT1 | P19440 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286794 | 0.87 | ALDH1A1 (0.43) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL36891321 | 0.87 | ALDH1A1 (0.43) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL13980589 | 0.75 | ALDH1A1 (0.42) | ALDH1A1ALOX15KDM4EHPGDMAPK1 | |
| SCHEMBL5753321 | 0.74 | ALDH1A1 (0.40) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL16116287 | 0.71 | PARP1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL29354955 | 0.71 | PARP1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL5749754 | 0.71 | ALDH1A1 (0.38) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL8765423 | 0.71 | TRPA1 (0.50) | ALDH1A1ALOX15KDM4EHSD17B10TSHR | |
| SCHEMBL5754927 | 0.71 | TSHR (0.40) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL29083019 | 0.71 | ALDH1A1 (0.44) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549613-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | Abbott Laboratories (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033419-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | ABBOTT LABORATORIES (US) | 2004-04-22 | — | — | WO | disclosed |