Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204093 | 1.00 | CRHR1 (0.42) | CRHR1CNR1CCR4HSP90AA1HSP90AB1 | |
| SCHEMBL6204591 | 0.99 | CRHR1 (0.43) | CRHR1CNR1CCR4HSP90AA1HSP90AB1 | |
| SCHEMBL6205707 | 0.92 | CRHR1 (0.43) | CRHR1CNR1CCR4LIMK1LIMK2 | |
| SCHEMBL6203747 | 0.91 | CRHR1 (0.44) | CRHR1CNR1CCR4LIMK1LIMK2 | |
| SCHEMBL6201596 | 0.89 | CRHR1 (0.48) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6204028 | 0.89 | CRHR1 (0.48) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6203274 | 0.88 | CNR1 (0.40) | CRHR1CNR1CCR4LIMK1LIMK2 | |
| SCHEMBL6204671 | 0.88 | CRHR1 (0.49) | CRHR1CNR1HSP90AA1HSP90AB1CDC7 | |
| SCHEMBL6203666 | 0.87 | CRHR1 (0.50) | CRHR1CNR1 | |
| SCHEMBL6202389 | 0.83 | CRHR1 (0.44) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |