Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.48 |
| ▸ | CNR1 | P21554 | 4/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201596 | 1.00 | CRHR1 (0.48) | CRHR1CNR1CDC7DBF4PDE2A | |
| SCHEMBL6204671 | 0.99 | CRHR1 (0.49) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6203522 | 0.89 | CRHR1 (0.41) | CRHR1PDE2A | |
| SCHEMBL6204093 | 0.89 | CRHR1 (0.42) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6201218 | 0.89 | CRHR1 (0.42) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6204600 | 0.88 | CRHR1 (0.46) | CRHR1CNR1PDE2A | |
| SCHEMBL6204591 | 0.88 | CRHR1 (0.43) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6203666 | 0.88 | CRHR1 (0.50) | CRHR1CNR1 | |
| SCHEMBL6204277 | 0.82 | CRHR1 (0.45) | CRHR1CNR1 | |
| SCHEMBL6203153 | 0.82 | CRHR1 (0.45) | CRHR1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |