Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563983 | 0.88 | LOXL2 (0.55) | GAAALDH1A1MAPTLOXL2KDM4E | |
| Hydrochloric Acid SCHEMBL3766466 | 0.87 | LOXL2 (0.56) | GAAALDH1A1MAPTLOXL2KDM4E | |
| SCHEMBL27209672 | 0.82 | GAA (0.46) | GAAALDH1A1MAPTPLAAT3PLAAT5 | |
| SCHEMBL27209667 | 0.82 | GAA (0.46) | GAAALDH1A1MAPTPLAAT3PLAAT5 | |
| SCHEMBL6202444 | 0.82 | TAAR1 (0.53) | TAAR1LOXL2ACHELOXMAOB | |
| SCHEMBL6201445 | 0.81 | LMNA (0.64) | TAAR1CHRNA7ALDH1A1ACHE | |
| SCHEMBL25588033 | 0.79 | PRMT6 (0.50) | GAAALDH1A1MAPTPLAAT3PLAAT5 | |
| SCHEMBL2081785 | 0.77 | MAOB (0.50) | GAAALDH1A1MAPTKDM4EMAOB | |
| SCHEMBL6199971 | 0.77 | TAAR1 (0.62) | TAAR1ACHEMAOB | |
| SCHEMBL27209652 | 0.77 | GAA (0.49) | GAAALDH1A1MAPTKDM4EMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |