Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175911 | 0.92 | THRB (0.38) | IGF1RPTGS2ARPTGS1KMT2A | |
| SCHEMBL6174119 | 0.86 | PTGS2 (0.37) | IGF1RPTGS2ARPTGS1KMT2A | |
| SCHEMBL6174464 | 0.85 | IGF1R (0.41) | IGF1RARKMT2ATSHRLMNA | |
| SCHEMBL6176736 | 0.85 | MAT2A (0.38) | ARKMT2ATSHRLMNAHTT | |
| SCHEMBL6177630 | 0.84 | IGF1R (0.39) | TP53IGF1RARKMT2ATSHR | |
| SCHEMBL6201343 | 0.84 | PTGS2 (0.40) | TP53IGF1RPTGS2ARKMT2A | |
| SCHEMBL6175073 | 0.83 | IGF1R (0.38) | TP53IGF1RARKMT2ATSHR | |
| SCHEMBL6203204 | 0.83 | IGF1R (0.40) | TP53IGF1RARKMT2ATSHR | |
| SCHEMBL6174358 | 0.82 | NPC1 (0.39) | TP53ARKMT2ATSHRLMNA | |
| SCHEMBL6172914 | 0.82 | IGF1R (0.38) | TP53IGF1RPTGS2ARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |