Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.48 |
| ▸ | HTR2C | P28335 | 11/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198115 | 0.75 | HTR2A (0.57) | HTR2AHTR2CMAPTRAB9A | |
| SCHEMBL6201535 | 0.74 | HTR2A (0.55) | HTR2AHTR2CMAPTKMT2ARAB9A | |
| SCHEMBL6197652 | 0.72 | HTR2A (0.68) | HTR2AHTR2C | |
| SCHEMBL6201621 | 0.71 | HTR2A (0.67) | HTR2AHTR2CMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6194256 | 0.70 | RAB9A (0.49) | HTR2AMAPTKMT2AALDH1A1RAB9A | |
| SCHEMBL6198377 | 0.70 | HTR2A (0.65) | HTR2AHTR2CMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6197155 | 0.69 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL5063293 | 0.69 | HTR2A (0.71) | HTR2AHTR2C | |
| SCHEMBL6199479 | 0.69 | HTR2A (0.64) | HTR2AHTR2CMAPTRAB9A | |
| SCHEMBL6199536 | 0.68 | HTR2A (0.54) | HTR2AHTR2CKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |