Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653282 | 0.75 | F2 (0.49) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL27921277 | 0.75 | CES2 (0.55) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL28845197 | 0.74 | CES2 (0.64) | CES2CES1SMN1; SMN2DAONPC1 | |
| Trifluoroacetic Acid SCHEMBL5223817 | 0.72 | DAO (0.50) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL10441485 | 0.72 | HPGDS (0.58) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL27610864 | 0.72 | CES2 (0.61) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL8457507 | 0.71 | GSK3B (0.56) | CES2CES1SMN1; SMN2DAONPC1 | |
| Potassium Ion SCHEMBL10701746 | 0.71 | CES2 (0.50) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL27921510 | 0.71 | CES2 (0.50) | CES2CES1SMN1; SMN2DAONPC1 | |
| SCHEMBL17065796 | 0.71 | CES2 (0.65) | CES2CES1SMN1; SMN2DAONPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525199-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | Argenta Discovery Limited (GB) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004013130-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2004-02-12 | — | — | WO | disclosed |