Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203614 | 0.91 | CRHR1 (0.70) | CRHR1SCN9ABRD4 | |
| SCHEMBL7477682 | 0.90 | CRHR1 (0.57) | CRHR1SCN9ABRD4 | |
| SCHEMBL7477918 | 0.86 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL6201263 | 0.84 | CRHR1 (0.62) | CRHR1SCN9ABRD4 | |
| SCHEMBL7477292 | 0.83 | CRHR1 (0.52) | CRHR1BRD4 | |
| SCHEMBL5410057 | 0.82 | CRHR1 (0.86) | CRHR1 | |
| SCHEMBL7482570 | 0.82 | CRHR1 (0.57) | CRHR1BRD4 | |
| SCHEMBL7476681 | 0.80 | CRHR1 (0.58) | CRHR1SCN9ABRD4 | |
| SCHEMBL7473622 | 0.80 | CRHR1 (0.58) | CRHR1SCN9ABRD4 | |
| SCHEMBL7474865 | 0.80 | CRHR1 (0.57) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | disclosed |