Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6083842 | 0.86 | MAPT (0.36) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6083851 | 0.86 | MAPT (0.36) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6086423 | 0.85 | TSHR (0.46) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6086056 | 0.84 | POLB (0.44) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6085763 | 0.81 | TP53 (0.37) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6085797 | 0.80 | NPC1 (0.42) | HPGDUSP2POLBSMN1; SMN2TSHR | |
| SCHEMBL6084819 | 0.79 | ALDH1A1 (0.44) | HPGDHSD17B10POLBSMN1; SMN2TSHR | |
| SCHEMBL6202643 | 0.77 | RAB9A (0.44) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6084903 | 0.77 | MEN1 (0.44) | HPGDUSP2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6085149 | 0.75 | MAOB (0.49) | POLBSMN1; SMN2ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |