Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200981 | 0.90 | NPC1 (0.38) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6085140 | 0.82 | MAPT (0.47) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6085147 | 0.82 | MAPT (0.47) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6085642 | 0.81 | MAPT (0.55) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6085323 | 0.79 | MAPT (0.55) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6202021 | 0.77 | HPGD (0.33) | MAPTNPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL6086476 | 0.75 | RAB9A (0.70) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6085669 | 0.75 | MAPT (0.47) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6086996 | 0.74 | ALDH1A1 (0.44) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL6086993 | 0.74 | ALDH1A1 (0.44) | RAB9AMAPTNPC1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |