Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GGT1 | P19440 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 6/20 | 0.45 |
| ▸ | RXRB | P28702 | 5/20 | 0.45 |
| ▸ | RXRG | P48443 | 4/20 | 0.45 |
| ▸ | IDO1 | P14902 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17596594 | 0.89 | RXRA (0.50) | KDM4EHSD17B10ALDH1A1ESR1ITGB3 | |
| SCHEMBL5833456 | 0.88 | RXRA (0.49) | KDM4EHSD17B10ALDH1A1ESR1ITGB3 | |
| SCHEMBL7206062 | 0.86 | RXRA (0.50) | KDM4EHSD17B10ALDH1A1ESR1ITGB3 | |
| SCHEMBL31312989 | 0.80 | BCL2L1 (0.54) | TSHRRXRARXRBRXRGIDO1 | |
| SCHEMBL11449146 | 0.79 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1ESR1ITGB3 | |
| SCHEMBL5657571 | 0.79 | RXRA (0.53) | RXRARXRBRXRGIDO1 | |
| SCHEMBL10496464 | 0.79 | PTGS2 (0.61) | KDM4EHSD17B10ALDH1A1ESR1ITGB3 | |
| SCHEMBL3727164 | 0.77 | RXRA (0.48) | ALDH1A1RXRARXRBRXRGLMNA | |
| SCHEMBL6204995 | 0.75 | PGR (0.46) | KDM4EHSD17B10ALDH1A1ESR1ITGB3 | |
| SCHEMBL5659543 | 0.74 | RXRB (0.59) | KDM4ERXRARXRBRXRGIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492795-A1 | 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003084961-A1 | 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-10-16 | — | — | WO | disclosed |