Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | DDO | Q99489 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15200742 | 0.90 | KMT2A (0.43) | MEN1PGRKMT2AMAP3K5NPC1 | |
| SCHEMBL39522 | 0.88 | GRIN2D (0.49) | MEN1PGRKMT2AMAP3K5PTGS2 | |
| SCHEMBL9267768 | 0.86 | DAO (0.39) | MAP3K5NPC1RAB9ADAODDO | |
| SCHEMBL7818937 | 0.85 | PTGS2 (0.44) | MEN1PGRKMT2AMAP3K5NPC1 | |
| SCHEMBL2485564 | 0.84 | MEN1 (0.45) | MEN1KMT2AMAP3K5NPC1RAB9A | |
| SCHEMBL852747 | 0.83 | KMT2A (0.55) | MEN1PGRKMT2ANPC1RAB9A | |
| SCHEMBL7862448 | 0.83 | KMT2A (0.38) | MEN1PGRKMT2ANPC1PTGS2 | |
| SCHEMBL2483507 | 0.81 | KDM4E (0.50) | KMT2AMAP3K5NPC1RAB9ADAO | |
| SCHEMBL7563981 | 0.79 | GPBAR1 (0.40) | MEN1PGRKMT2APTGS2KDM4E | |
| SCHEMBL7829055 | 0.78 | PTGS2 (0.40) | MEN1PGRKMT2APTGS2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634931-A1 | THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES | Pharmacia & Upjohn Aktiebolag (SE) | 1995-01-25 | — | — | EP | claimed |
| WO-1993019756-A9 | THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES | — | 1994-10-27 | — | — | WO | claimed |
| WO-1993019756-A1 | THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES | KABI PHARMACIA AB (SE) | 1993-10-14 | — | — | WO | claimed |
| EP-1511732-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | Active Biotech AB (SE) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003106424-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2003-12-24 | — | — | WO | disclosed |
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |
| EP-0758327-A1 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-19 | — | — | EP | disclosed |
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1993019756-A9 | THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES | — | 1994-10-27 | — | — | WO | disclosed |
| EP-0516725-A1 | NEW USE. | KABI PHARMACIA AB (SE) | 1992-12-09 | — | — | EP | disclosed |
| WO-1991012804-A1 | NEW USE | KABI PHARMACIA AB (SE) | 1991-09-05 | — | — | WO | disclosed |