SCHEMBL6202235

SCHEMBL6202235

COc1ccc(C(=O)C(NC(C)CCO)c2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.45
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HTT P42858 2/20 0.44
RAB9A P51151 2/20 0.44
LMNA P02545 1/20 0.44
NPC1 O15118 1/20 0.44
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
CYP2D6 P10635 1/20 0.42
CA1 P00915 3/20 0.42
CA2 P00918 3/20 0.42
TAS1R3 Q7RTX0 1/20 0.42
TAS1R1 Q7RTX1 1/20 0.42
CYP1A2 P05177 1/20 0.41
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6203407 0.89 ALDH1A1 (0.46) SLC2A1ALDH1A1SMN1; SMN2HTTRAB9A
SCHEMBL6222701 0.81 CA1 (0.47) SLC2A1ALDH1A1SMN1; SMN2RAB9ANPC1
SCHEMBL6323033 0.78 TAS1R3 (0.45) SLC2A1ALDH1A1SMN1; SMN2HTTRAB9A
SCHEMBL23628704 0.76 TAS1R3 (0.61) ALDH1A1SMN1; SMN2HTTRAB9ALMNA
SCHEMBL6320430 0.75 NPC1 (0.53) ALDH1A1SMN1; SMN2RAB9ALMNANPC1
SCHEMBL22215186 0.74 MDM2 (0.55) SLC2A1ALDH1A1SMN1; SMN2HTTRAB9A
SCHEMBL6275504 0.73 HAT1 (0.54) ALDH1A1SMN1; SMN2RAB9ALMNANPC1
SCHEMBL6219820 0.73 MAPT (0.48) ALDH1A1SMN1; SMN2HTTRAB9ALMNA
SCHEMBL6539670 0.71 ALDH1A1 (0.49) SLC2A1ALDH1A1RAB9ANPC1MEN1
SCHEMBL6205477 0.71 HDAC3 (0.55) SLC2A1ALDH1A1SMN1; SMN2HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1549600-A1 KETONES AstraZeneca AB (SE) 2005-07-06 EP disclosed
WO-2004011410-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2004-02-05 WO disclosed