Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27754716 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL27754714 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL11200342 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL2947190 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL2947193 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL28163310 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL27625173 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2TDP1ALDH1A1GLALMNA | |
| SCHEMBL11141005 | 0.71 | LMNA (0.50) | SMN1; SMN2TDP1LMNAMBTD1L3MBTL3 | |
| SCHEMBL18241853 | 0.71 | PARP1 (0.44) | SMN1; SMN2ALDH1A1GAAHPGDHTT | |
| SCHEMBL27754552 | 0.70 | HSP90AA1 (0.46) | SMN1; SMN2ALDH1A1GLASIGMAR1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |