Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202539 | 0.85 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6KDM4E | |
| SCHEMBL6203475 | 0.75 | SMN1; SMN2 (0.45) | KDM4EALDH1A1MAPTHTTHSD17B10 | |
| SCHEMBL3444371 | 0.73 | CDK2 (0.36) | MAPTCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3445020 | 0.72 | SYK (0.35) | MAPTCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL6203471 | 0.72 | CCNB2 (0.46) | KDM4EALDH1A1MAPTHTTHSD17B10 | |
| SCHEMBL3445672 | 0.71 | CDK2 (0.46) | ALDH1A1LMNANFKB1RAB9ASMN1; SMN2 | |
| SCHEMBL3445346 | 0.71 | CDK1 (0.41) | KDM4EMAPTRAB9ACCNB2CDK1 | |
| SCHEMBL6201274 | 0.71 | CLK1 (0.34) | HDAC3HDAC1HDAC2HDAC6MAPT | |
| SCHEMBL3444397 | 0.70 | CDK2 (0.46) | CDK1CCNB1 | |
| SCHEMBL3444749 | 0.69 | CDK2 (0.46) | CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |