Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886568 | 0.79 | L3MBTL1 (0.62) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL2886563 | 0.79 | L3MBTL1 (0.62) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL17549648 | 0.77 | L3MBTL1 (0.54) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL17767290 | 0.77 | KMT2A (0.57) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL17767291 | 0.77 | KMT2A (0.57) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL28814486 | 0.77 | MTNR1B (0.55) | RAB9AKMT2AMEN1POLBTP53 | |
| SCHEMBL28000883 | 0.76 | MAPT (0.57) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL13282701 | 0.76 | POLB (0.67) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL2485948 | 0.76 | POLB (0.67) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL12174660 | 0.75 | L3MBTL1 (0.62) | NPC1RAB9AKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |