Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 7/20 | 0.36 |
| ▸ | HTR2B | P41595 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD1 | O95696 | 1/20 | 0.35 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587625 | 0.85 | HTT (0.44) | MAPTKCNH2HTR2CHTR2BHTR2A | |
| SCHEMBL5238079 | 0.80 | HTR2C (0.38) | MAPTKCNH2HTR2CHTR2BHTR2A | |
| Tert-Butyl Formate SCHEMBL27791266 | 0.75 | HTT (0.36) | KCNH2HTR2CHTR2BHTR2ABRPF1 | |
| SCHEMBL28936152 | 0.75 | MAPT (0.51) | MAPTPOLBHTR2CHTR7BRPF1 | |
| SCHEMBL15770549 | 0.73 | LATS1 (0.49) | MAPTPOLBKCNH2HTR2CHTR2B | |
| Ammonia Solution, Strong SCHEMBL27277144 | 0.72 | CYP1A2 (0.51) | MAPTPOLBHTR2CHTR2BHTR2A | |
| SCHEMBL16580890 | 0.71 | ALDH1A1 (0.49) | MAPTPOLBKCNH2HTTKMT2A | |
| SCHEMBL20694909 | 0.70 | HTR1A (0.45) | MAPTHTR7HTTKMT2AACHE | |
| SCHEMBL15210112 | 0.70 | KMT2A (0.44) | HTR2CHTR2BHTR2AHTTKMT2A | |
| SCHEMBL11876376 | 0.70 | HTR2C (0.52) | MAPTPOLBHTR2CHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | Amgen Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003101985-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC. (US) | 2003-12-11 | — | — | WO | disclosed |